Evaluating Weight of Evidence in the Mystery of Balkan Endemic Nephropathy
نویسندگان
چکیده
منابع مشابه
Role of exposure analysis in solving the mystery of Balkan endemic nephropathy.
We evaluated the role of exposure analysis in assessing whether ochratoxin A or aristolochic acid are the agents responsible for causing Balkan endemic nephropathy. We constructed a framework for exposure analysis using the lessons learned from the study of endemic goiter within the context of an accepted general model. We used this framework to develop an exposure analysis model for Balkan end...
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Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
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Introduction Balkan endemic nephropathy (BEN) is a chronic irreversible interstitial sclerosis, for which over the last 25 years, chronic exposure to aristolochic acid from the contaminated cereal seeds has been considered the most likely cause. The aim of our research is to reevaluate trends of disease and to try to obtain new information about practical implementing of in-field screening of B...
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The correlation between the geographic occurrence of Balkan endemic nephropathy (BEN) and low rank Pliocene lignites is striking. Comparison of mass spectra of methanol extracts from lignite samples collected in the vicinity of two endemic villages, with mass spectra of methanol extracts higher grade coals, shows the presence of many more potentially nephrotoxic compounds, and much higher total...
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RENAL INTERSTITIAL FIBROSIS IS A MAJOR FEATURE OF BALKAN ENDEMIC NEPHROPATHY (BEN) G. A. Müller, M. Zeisberg, F Strutz Dept. of Nephrology & Rheumatology, Georg-August Universität Göttingen, 37075 Göttingen, Germany Balkan Nephropathy is a common renal disease in the Balkan region which often leads to endstage renal failure. The pathogenesis of this disease is still unknown, however, the pathwa...
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ژورنال
عنوان ژورنال: Risk Analysis
سال: 2014
ISSN: 0272-4332
DOI: 10.1111/risa.12239